Pylorus cancer is a type of gastric (stomach) cancer that develops in the pylorus, the part of the stomach that connects to the small intestine. The strongest known risk factor is chronic infection with the bacterium H. pylori, which can lead to long-term inflammation and damage to the stomach lining. Other risk factors include a high intake of salt and pickled foods. Treatment options depend on the stage and location of the cancer and can include surgery, chemotherapy, or targeted therapy.

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Pylorus Cancer: Understanding a Rare Type of Stomach Cancer
By Dhurga | November 8, 2025

🩺 Overview

Pylorus cancer is a type of gastric (stomach) cancer that develops in the pylorus, the lower portion of the stomach that connects to the small intestine (duodenum). This region plays a crucial role in controlling the passage of digested food from the stomach into the intestines — and when cancer develops here, it can significantly affect digestion and overall health.

🧫 Causes and Risk Factors

The strongest known risk factor for pylorus cancer is chronic infection with the bacterium Helicobacter pylori (H. pylori), which can cause long-term inflammation and damage to the stomach lining. Over time, this can lead to precancerous changes and eventually cancer formation.

Other important risk factors include:

  • 🍲 High intake of salty or pickled foods

  • 🍖 Smoked or preserved meats

  • 🚬 Smoking and alcohol consumption

  • 🧬 Family history of stomach cancer

  • 💊 Certain gastric conditions, such as chronic gastritis or gastric ulcers

⚠️ Symptoms

Symptoms of pylorus cancer can vary, especially in early stages. Common signs include:

  • Persistent indigestion or bloating

  • Abdominal pain or discomfort after eating

  • Loss of appetite and unintended weight loss

  • Nausea or vomiting

  • Feeling full quickly after small meals

  • In later stages, vomiting blood or black stools may occur

🧬 Diagnosis

Doctors may use a combination of tests such as:

  • Endoscopy (to view the stomach lining and take tissue samples)

  • Biopsy (to confirm cancer cells)

  • CT or MRI scans (to determine the stage and spread of cancer)

💊 Treatment Options

Treatment depends on the stage, size, and location of the tumor, as well as the patient’s overall health. Common approaches include:

  • Surgery: To remove part or all of the stomach (gastrectomy)

  • Chemotherapy: To destroy remaining cancer cells or shrink tumors before surgery

  • Targeted Therapy: To attack specific cancer cell mechanisms

  • Palliative Care: To relieve symptoms and improve quality of life in advanced stages

🌿 Prevention and Lifestyle Tips

  • Reduce consumption of salty, smoked, and pickled foods

  • Eat a diet rich in fruits and vegetables

  • Get tested and treated for H. pylori infections early

  • Avoid smoking and excessive alcohol use

💬 Conclusion

Pylorus cancer, though uncommon, is a serious form of gastric cancer that requires early detection and prompt treatment. Maintaining a healthy diet, managing H. pylori infections, and regular medical checkups are key steps toward prevention and better outcomes.

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